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Canine leucocyte adhesion deficiency in Irish red and white setters
Author(s) -
Debenham S. L.,
Millington A.,
Kijas J.,
Andersson L.,
Binns M.
Publication year - 2002
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2002.tb00032.x
Subject(s) - medicine , white (mutation) , irish , pathology , genetics , linguistics , philosophy , gene , biology
Seventy‐six Irish red and white setter samples were tested for the recently documented CD18 point mutation which manifests as canine leucocyte adhesion deficiency (CLAD) in Irish setters. Six carrier dogs were identified, all originating from a lineage within which sporadic deaths from symptoms consistent with CLAD had been observed. This is the first demonstration that the CLAD mutation exists outside the Irish setter population, confirming that the mutation is present in a significant minority of Irish red and white setters. Routine testing by breeders to identify carrier animals will enable the eradication of CLAD from the Irish red and white setter population.