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Diagnosis of cerebellar cortical degeneration in a Scottish terrier using magnetic resonance imaging
Author(s) -
Merwe L. L. van der,
Lane E.
Publication year - 2001
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2001.tb02491.x
Subject(s) - medicine , cerebellum , pathology , magnetic resonance imaging , cerebellar degeneration , ataxia , degeneration (medical) , cerebellar hypoplasia (non human) , hypoplasia , cerebellar ataxia , atrophy , cerebrospinal fluid , anatomy , paraneoplastic cerebellar degeneration , radiology , psychiatry , antibody , immunology , autoantibody
Primary cerebellar cortical degeneration (CCD), also termed abiotrophy, is the spontaneous premature degeneration of fully differentiated neurological tissue. Cerebellar hypoplasia shares many morphological features with primary CCD, both conditions being characterised by decreased cerebellar size, with reduced numbers of Purkinje and granular cells. CCD has been identified in many canine breeds. This is the first report of the syndrome in a Scottish terrier. The patient presented with mild, gradually progressive ataxia. Survey radiographs of the cervical spine and cerebrospinal fluid (CSF) analysis were normal. CSF distemper and Toxoplasma titres were negative. A diagnosis of cerebellar atrophy was made based on magnetic resonance imaging. The progressive clinical signs suggested cerebellar degeneration rather than hypoplasia. On necropsy, the cerebellum showed macroscopic and microscopic changes consistent with primary CCD.