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Multiple endocrine neoplasia type 1 in a crossbred dog
Author(s) -
Walker M. C.,
Jones B. R.,
Guildford W. G.,
Burbidge H. M.,
Alley M. R.
Publication year - 2000
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2000.tb03165.x
Subject(s) - medicine , polyuria , polydipsia , hypercalcaemia , dexamethasone suppression test , endocrinology , dexamethasone , multiple endocrine neoplasia , endocrine system , acth stimulation test , parathyroid gland , adrenocorticotropic hormone , mitotane , parathyroid hormone , hormone , chemotherapy , calcium , biochemistry , chemistry , diabetes mellitus , gene
Multiple endocrine neoplasia type 1 was diagnosed in a 12‐year‐old male crossbred dog. Relevant history included polyuria and polydipsia of four months' duration. Physical examination revealed abdominal enlargement, seborrhoea and polypnoea. Diagnostic tests indicated hypercalcaemia, elevated serum alkaline phosphatase and alanine aminotransferase, an exaggerated response to adrenocorticotropic stimulation of the adrenal gland, lack of cortisol suppression with a low dose dexamethasone suppression test and suppression of cortisol secretion with a high dose dexamethasone test. An enlarged right parathyroid gland was removed surgically and confirmed histopathologically to be a parathyroid adenoma. The pituitary‐dependent hyperadrenocorticism was treated successfully with mitotane for 14 months before the patient was euthanased for an unrelated problem.