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Successful long‐term treatment of congenital nephrogenic diabetes insipidus in a dog
Author(s) -
Takemura N.
Publication year - 1998
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1998.tb03714.x
Subject(s) - medicine , polyuria , polydipsia , nephrogenic diabetes insipidus , hydrochlorothiazide , urinalysis , diabetes insipidus , hypernatremia , diabetic ketoacidosis , endocrinology , urology , pediatrics , diabetes mellitus , urine , sodium , blood pressure , chemistry , organic chemistry
A two‐year‐old intact male shiba inu dog with excessive polyuria and polydipsia (PU‐PD) was diagnosed as having congenital nephrogenic diabetes insipidus based on clinical findings, the results of urinalysis, blood examinations, a modified water deprivation test and a low dose dexamethasone suppression test. The owner was advised to provide adequate access to drinking water, and treatment with a low dose of hydrochlorothiazide (2 mg/kg, twice daily) together with a low sodium diet was initiated. As a result, the daily water intake decreased significantly from 6500 to 7500 ml/day (800 to 980 ml/kg/day) to 1400 to 1900 ml/day (170 to 230 ml/kg/day) and the clinical signs associated with the PU‐PD and dehydration improved over the following two years.