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Superficial necrolytic dermatitis and a pancreatic endocrine tumour in a dog
Author(s) -
Torres S.,
Johnson K.,
McKeever P.,
Hardy R.
Publication year - 1997
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1997.tb03358.x
Subject(s) - medicine , endocrine system , glucagon , skin biopsy , biopsy , pathology , glucagonoma , histopathological examination , gastroenterology , insulin , hormone
A 13‐year‐old dog was referred for a severe dermatological problem of 12 months duration. Skin biopsy results were compatible with superficial necrolytic dermatitis. The only laboratory abnormalities were hyperglycaemia and hyperglucagonaemia. These findings suggested a pancreatic endocrine tumour in association with superficial necrolytic dermatitis. Abdominal ultrasound examination was unremarkable. The dog was euthanased due to the lack of clinical improvement following symptomatic therapy. Postmortem examination revealed a pancreatic endocrine tumour with liver metastases. Pancreatic endocrine tumour cells were immunoreactive for glucagon, insulin and islet amyloid polypeptide.