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Role of 1–123 serum amyloid Srotein in the etection of familial amyloidosis in Oriental cats
Author(s) -
Piirsalu K.,
McLean R.,
Zuber R.,
Bannistert K.,
Penglis S.,
Bellen J.,
Bais R.
Publication year - 1994
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1994.tb03824.x
Subject(s) - cats , medicine , amyloidosis , pathology , amyloid (mycology) , biopsy , serum amyloid p component , c reactive protein , inflammation
Oriental cats are subject to familial amyloidosis which primarily involves the liver. Scintigraphic imaging using I‐123 serum amyloid P component (SAP) was performed in 23 cats at varying risks of amyloidosis. Scans showed marked tracer accumulation in the liver in 16 of the cats. Histological confirmation of amyloidosis was obtained in all six cats that underwent biopsy. Abnormal hepatic uptake correlated with rapid clearance of tracer from the blood. This non‐invasive test has potential value as a screening procedure for the detection of amyloidosis.