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Central core myopathy in a great dane
Author(s) -
Targett M. P.,
Franklin R. J. M.,
Olby N. J.,
Dyce J.,
Anderson J. R.,
Houlton J. E. F.
Publication year - 1994
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1994.tb02547.x
Subject(s) - medicine , exercise intolerance , myopathy , muscle biopsy , core (optical fiber) , pathology , biopsy , heart failure , materials science , composite material
An eight‐month‐old female great dane was referred for investigation of exercise intolerance that had developed progressively over one month. Examination revealed poor muscle mass, elevated plasma levels of muscle‐associated enzymes and electromyographic abnormalities. The dog was euthanased at 15 months old because of severe exercise intolerance. Tissue obtained by biopsy and at post mortem examination revealed prominent well defined central core structures within most muscle fibres, but no other abnormalities. The condition was diagnosed as a central core myopathy.