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Multifocal idiopathic pyogranulomatous bone disease in a dog
Author(s) -
Canfield P. J.,
Malik R.,
Davis P. E.,
Martin P.
Publication year - 1994
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1994.tb01721.x
Subject(s) - medicine , pathology , osteolysis , osteomyelitis , osteosclerosis , appendicular skeleton , tarsal bone , rib cage , osteochondrosis , anatomy , radiology , surgery , ankle
Disseminated, multifocal idiopathic pyogranulomatous bone disease in a five‐year‐old neutered female crossbred cattle dog is described. The dog was presented for neck pain and reluctance to exercise. Radiography demonstrated polyostotic bone disease, the predominant change consisting of a mottled pattern of osteosclerosis interspersed with punctate foci of osteolysis. Numerous bones of the axial and appendicular skeleton were affected including cervical vertebrae, ribs, scapulae and humeri. Biopsy revealed sterile pyogranulomatous osteomyelitis. This was confirmed at necropsy which showed that lesions were restricted to bone. Idiopathic granulomatous or pyogranulomatous conditions have been described in the dog in relation to skin but not bone. In people, idiopathic granulomatous bone disease is one of a group of conditions collectively called histiocytosis X, which are thought to be immunoregulatory disorders related to Tlymphocyte suppressor cell deficiency and Langerhans' cell proliferation.