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Arteriosclerosis of extramural coronary arteries in labradors with congestive heart failure
Author(s) -
Kelly D. F.,
Gaskell C J.,
Lee M. A.
Publication year - 1992
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1992.tb01199.x
Subject(s) - medicine , cardiology , heart failure , coronary arteries , cardiac glycoside , stenosis , arteriosclerosis , artery , chemistry , organic chemistry , ouabain , sodium
Two adult male labrador dogs had short clinical histories of congestive cardiac failure lasting only six weeks. Cardiac function deteriorated rapidly in both dogs, in spite of symptomatic treatment with cardiac glycoside, diuretic and p‐adrenergic blocker. Necropsies revealed ascites and pulmonary congestion, but no macroscopic evidence of valvular or myocardial disease adequate to account for the cardiac dysfunction. Both dogs had extensive stenosis of extramural coronary arteries. This unusual vascular lesion comprised fibroelastic intimal thickening, discontinuity of internal elastic lamella and focal atrophy of medial smooth muscle. It seems likely that cardiac failure in these dogs was associated with myocardial underperfusion caused by extensive non‐thrombotic, non‐atherogenic stenosis of extramural coronary arteries.