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Treatment of canine nasal aspergillosis/penicilliosis with fluconazole (UK‐49,858)
Author(s) -
Sharp N. J. H.,
Harvey C. E.,
O'Brien J. A.
Publication year - 1991
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1991.tb00868.x
Subject(s) - medicine , fluconazole , aspergillosis , aspergillus , mycosis , serology , gastroenterology , dermatology , surgery , antifungal , immunology , microbiology and biotechnology , antibody , biology
Fluconazole was given orally at dose rates of 2–5 mg/kg to five dogs, and at 5‐0 mg/kg in a further five dogs, to treat naturally occurring rhinitis/sinusitis caused by Aspergillus or Penicillium species. Infection was confirmed in all dogs by clinical, radiological, rhinoscopical, serological and mycological examination. Treatment was well tolerated. Infection was eliminated in two dogs with penicilliosis, two dogs with aspergillosis, and two dogs where the organism was identified as either Aspergillus or Penicilli‐um species on the basis of immunohistochemical labelling. These six dogs were disease free at reexamination, and have remained so over a median follow‐up period of 27 months.