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Pathology of two possible genodermatoses
Author(s) -
Rest J. R.
Publication year - 1989
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1989.tb01547.x
Subject(s) - medicine , pathology , dermatology , hyperpigmentation , dermatomyositis , papillomatosis , dermis , atrophy , acanthosis , hyperkeratosis
A United Kingdom bred Shetland sheepdog puppy was presented with crusting, hyper‐ and hypopigmented alopecic skin lesions on the face, nose, tail and extensor surfaces of the lower limbs. Histologically, the lesions were characterised by vacuolation of the basal epidermis with formation of colloid bodies and vesication. There was accompanying dermal oedema with moderate infiltrates of predominantly mononuclear cells. Hyperpigmentation, acanthosis and follicular atrophy correlated with the clinical appearance of chronic lesions. Skin scrapings for ringworm and mites were negative as was direct immunofluorescence. A full post mortem examination was conducted. Histological examination of five muscle sites, including the temporalis and masseter muscles did not show any significant abnormality. The condition is discussed in relation to the pathological criteria required for diagnosis and compared with published reports of epidermolysis bullosa and dermatomyositis in collies and Shetland sheepdogs. Confirmation of the clinical diagnosis of cutaneous asthenia (Ehlers‐Danlos syndrome) was made pathologically in two domestic shorthaired cats from the same area of the United Kingdom. Histological and electron microscopic findings are described and compared with other published reports.