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Inherited bleeding disorders of dogs and cats
Author(s) -
Littlewood J. D.
Publication year - 1989
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1989.tb01519.x
Subject(s) - medicine , haemophilia a , autosomal recessive trait , asymptomatic , offspring , haemophilia , heterozygote advantage , cats , factor ix , asymptomatic carrier , von willebrand disease , pediatrics , von willebrand factor , physiology , genetics , platelet , allele , pregnancy , gene , biology
The congenital bleeding disorders of domestic animals usually mimic closely the same disorders in man and are inherited in a similar fashion. Classical haemophilia (haemophilia A, factor VIII deficiency) and haemophilia B (factor IX deficiency) occur in both dogs and cats and are sex‐linked conditions. Affected animals are almost always male and heterozygote females are asymptomatic carriers. Offspring of a carrier female have a 50 per cent chance of inheriting the defective X‐chromosome and, on average, half of the sons will be affected and half of the daughters will be carriers. Diagnosis of affected animals is confirmed by specific factor assay. Carriers may be identified with a statistical certainty of greater than 80 per cent. Canine von Willebrand's disease is a less severe disorder due to a defect of platelet adhesion. It is an autosomal trait, inherited in most breeds in an incompletely dominant fashion.