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Pharmacokinetics and bioavailability of dapsone in the beagle dog
Author(s) -
Hekman P.,
Rens P.,
Rietvel E. C.,
Coert A.
Publication year - 1989
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1989.tb01506.x
Subject(s) - beagle , bioavailability , medicine , pharmacokinetics , dapsone , plasma concentration , pharmacology , oral administration , plasma levels , area under the curve , bioequivalence , dermatology
The plasma concentration of dapsone (4,4′‐diaminodiphenyl‐sulphone) was measured after intravenous and oral administration (±5 mg/kg) to female beagle dogs. Analysis of the plasma concentrations showed a bioavailability of the tablet of 99 per cent. The biological half‐life in plasma was estimated to be 13±4 hours after intravenous and 11±5 hours after oral application. In order to test the pharmacokinetic models for their validity a chronic experiment was performed with one dog. The plasma curve, predicted from the oral single‐dose data, closely matched the measured experimental data points, which indicates that the applied models are likely to be correct.