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Plasma bile acids, lactate dehydrogenase and sulphobromophthalein retention test in canine carbon tetrachloride intoxication
Author(s) -
AGUILERATEJERO E.,
MAYERVALOR R.,
GOMEZCARDENAS G.
Publication year - 1988
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1988.tb02171.x
Subject(s) - lactate dehydrogenase , medicine , carbon tetrachloride , bile acid , hepatic function , aspartate aminotransferases , liver function tests , gastroenterology , biochemistry , enzyme , alanine transaminase , chemistry , organic chemistry
This paper studies the progression of various hepatic function tests (fasting and post prandial plasma bile acids, lactate dehydrogenase [LDH], hydroxybutyrate dehydrogenase [HBDH], LDH isoenzymogram, and 45 minutes sulphobromophthalein retention) in a classic model of canine hepatic injury. Sulphobromphthalein and plasma bile acid determination are excellent indicators of hepatic damage. Post prandial bile acid quantification does not improve the diagnostic capacity of this test. LDH alters only in the first 48 hours after poisoning and the study of the HBDH/LDH ratio makes it possible to differentiate the origin of plasma LDH. LDH isoenzymogram is not a practical test for routine clinical diagnosis.