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Evaluation of a new non‐hormonal substance for terminating pregnancy in bitches in clinical trials
Author(s) -
OLIVAy O.,
COLOMBO G.,
NAVA G. A.,
CAIROLI F.
Publication year - 1987
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1987.tb05989.x
Subject(s) - medicine , pregnancy , clinical trial , endocrine system , hormone , obstetrics , genetics , biology
A new non‐hormonal contragestational agent (DL 717‐IT), the 2‐(4 chlorophenyl)‐s‐triazole |5,1‐a|‐isoquinoline, was tested in clinical trials to determine its efficacy for interrupting the pregnancy in the bitch. Five hundred and sixty‐five bitches were given a single intramuscular injection of the drug between the first and 15th day after the mating. Of the 475 bitches that received 2–5 mg/kg, 430 (90‐5 per cent) did not whelp at all, 15 (3‐2 per cent) delivered a few stillborn or weak puppies that died some hours after birth, and 30 (6‐3 per cent) delivered at least one normal live pup. Of 90 bitches treated with 3–5 mg/kg, 87 (96‐7 per cent) did not whelp at all, two (2‐2 per cent) delivered a few stillborn or weak puppies that died some hours after birth, and one (1 1 per cent) delivered normal live puppies. DL 717‐IT, owing to the high effectiveness and minimal side effects, must be considered a very reliable drug for the interruption of pregnancies in the bitch.