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The responsible use of chloramphenicol in small animal practice. 1. Pharmacological considerations
Author(s) -
KNIFTON A.
Publication year - 1987
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1987.tb01447.x
Subject(s) - medicine , chloramphenicol , pharmacokinetics , antibiotics , pharmacology , broad spectrum , cats , distribution (mathematics) , intensive care medicine , microbiology and biotechnology , biology , combinatorial chemistry , mathematical analysis , chemistry , mathematics
Three important criteria which the clinician should consider when selecting an antibiotic are its antibacterial spectrum, pharmacokinetic properties, and potential toxicity. Pharmacokinetics is a study of how the body handles drugs: that is, their absorption, distribution in the tissues (an antibiotic must reach the site of infection in effective concentration), metabolism and excretion. This article reviews these criteria with respect to chloramphenicol in dogs and cats.