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Nonspherocytic haemolytic anaemia due to phosphofructokinase deficiency in an English Springer Spaniel
Author(s) -
ROUDEBUSH PHILIP,
EASLEY J. ROGER,
HARVEY JOHN W.
Publication year - 1987
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1987.tb01444.x
Subject(s) - phosphofructokinase , medicine , breed , endocrinology , pyruvate kinase , glycolysis , biology , zoology , metabolism
A five‐year‐old female English Springer Spaniel was evaluated for chronic episodic anaemia, pigmenturia and icterus. There was increased erythrocyte pyruvate kinase activity, increased in vitro erythrocyte alkaline fragility, decreased erythrocyte 2,3‐diphosphoglycerate activity and severely decreased erythrocyte phosphofructokinase activity. The clinical features and haematological values were identical with erythrocyte phosphofructokinase deficiency and resulting nonspherocytic haemolytic anaemia recently described in this breed.