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Immune‐based non‐erosive inflammatory joint disease of the dog. 2. Polyarthritis/polymyositis syndrome
Author(s) -
BENNETT DAVID,
KELLY D. F.
Publication year - 1987
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1987.tb01315.x
Subject(s) - medicine , polymyositis , polyarthritis , prednisolone , anti nuclear antibody , joint pain , pathology , contracture , cyclophosphamide , myositis , dermatology , arthritis , immunology , autoantibody , antibody , surgery , chemotherapy
A connective tissue disorder characterized by non‐erosive polyarthritis and polymyositis has been identified in six young adult dogs. The diagnosis was based on the clinical features of stiffness, joint swelling, joint pain, muscle atrophy, muscle pain and contracture and the presence of chronic active inflammation in biopsies of muscle and synovium. A diagnosis of systemic lupus erythematosus was excluded by the absence of circulating antinuclear antibody. Five of the six dogs were of the spaniel breeds. Treatment was with cyclophosphamide and prednisolone. Only two dogs made an apparent recovery.