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Immune‐based non‐erosive inflammatory joint disease of the dog. 1. Canine systemic lupus erythematosus
Author(s) -
BENNETT DAVID
Publication year - 1987
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1987.tb01314.x
Subject(s) - medicine , polyarthritis , anti nuclear antibody , prednisolone , cyclophosphamide , immunology , immune system , systemic disease , disease , systemic lupus erythematosus , autoimmunity , antibody , arthritis , autoantibody , immunopathology , pathology , chemotherapy , gastroenterology
The features of 13 dogs with systemic lupus erythematosus (SLE) are described. Canine SLE is a multisystemic disease characterized by autoimmunity and immune complex hypersensitivity. The presence of antinuclear antibody in the blood is an important diagnostic feature. All 13 cases had a non‐erosive symmetrical polyarthritis. Autoimmune haemolytic anaemia was seen in five cases, thrombocytopenia in three, skin lesions in four; neurological involvement in one; and gastrointestinal signs in one. Treatment was with cytotoxic drugs(cyclophosphamide initially) and prednisolone.