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Canine nasal aspergillosis: serology and treatment with ketoconazole
Author(s) -
SHARP N.,
BURRELL M. H.,
SULLIVAN M.,
CERVANTESOLIVARES R. A.
Publication year - 1984
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1984.tb00462.x
Subject(s) - medicine , serology , aspergillosis , ketoconazole , alkaline phosphatase , surgery , gastroenterology , dermatology , antifungal , immunology , antibody , biochemistry , chemistry , enzyme
Seven cases of nasal aspergillosis in dogs were diagnosed using radiography, endoscopy, culture and serology. Treatment with oral ketoconazole (an imidazole derivative) at 40 mg/kg b. wt, alone or in combination with surgery resulted in three cures, while in four dogs this therapy was not successful. In all cases inappetance and hypoal‐buminaemia were noted and rises in levels of serum alkaline phosphatase (SAP) and alanine aminotransferase (ALT) were recorded in six of the seven cases. Serological monitoring was conducted during the period of therapy and in cases that recovered a fall in titre was noted.