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Extra‐neural lesions in experimental lead toxicosis of dogs
Author(s) -
HAMIR A. N.,
SULLIVAN N. D.
Publication year - 1983
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1983.tb00383.x
Subject(s) - medicine , cholestasis , hyperplasia , jaundice , pathology , lead poisoning , physiology , degeneration (medical) , lead (geology) , gastroenterology , biology , psychiatry , paleontology
A lead salt mixture was given orally to nine dogs at 5–10 mg/kg/day for periods varying from 14 to 152 days. Macroscopic lesions included reddening of bone marrow and gastric ulceration. Jaundice occurred in dogs receiving high total lead dosage. Histopathologically, periacinar fatty change in the liver was a consistent finding and at high doses of lead, this was accompanied by cholestasis and biliary hyperplasia. Testicular degeneration and aspermia was found in two of the three male dogs. Acid‐fast lead inclusions were present in the liver, kidney and osteoclasts.