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The effect of doxapram hydrochloride on cats anaesthetized with either Saffan or thiopentone sodium
Author(s) -
CURTIS R.,
EVANS J. M.
Publication year - 1981
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1981.tb01395.x
Subject(s) - doxapram , medicine , anesthesia , cats , respiratory rate , heart rate , respiratory minute volume , sodium , respiratory system , blood pressure , chemistry , organic chemistry
Doxapram hydrochloride as a 2% aqueous solution (Dopram V, A. H. Robins) was administered intravenously to cats anaesthetized with either Saffan (Glaxo) or 2 5% thiopentone sodium. A dose of 7 5 mg per kg resulted in an immediate and marked increase in respiratory rate and depth, and the heart rate also increased significantly. The administration of doxapram to cats anaesthetized with Saffan resulted in an average initial increase in minute volume of 181%; although the effect diminished rapidly, the tidal volume remained elevated for many minutes compared with controls. Doxapram hydrochloride would appear to be of value in the treatment of respiratory depression during anesthesia with either Saffan or thiopentone.