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Effect of feeding on plasma antibiotic concentrations in Greyhounds given ampicillin and amoxycillin by mouth
Author(s) -
Watson A. D. J.,
Egerton JR.
Publication year - 1977
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1977.tb05856.x
Subject(s) - ampicillin , medicine , dosing , antibiotics , amoxicillin , pharmacology , microbiology and biotechnology , biology
In a cross‐over study, six Greyhounds were dosed by mouth with ampicillin and amoxycillin at 20 mg/kg, using three different feeding regimens (no food, canned food prior to dosing, and dry food ad lib ) with each drug. Antibiotic levels in plasma were determined by microbiological assay at intervals after dosing. Plasma ampicillin concentrations tended to be lower in fed than in starved Greyhounds, but amoxycillin levels were relatively unaffected by feeding. In starved Greyhounds, ampicillin gave higher early levels than amoxycillin.