Premium
Effect of Estradiol, Testosterone, Cortisone Acetate, Somatotropin, Thyrotropin and Parathyroid Hormone on the Lumbar Intervertebral Disc in Growing Dogs *
Author(s) -
Paatsama S.,
Rissanen P.,
Rokkanen P.
Publication year - 1969
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1969.tb04670.x
Subject(s) - medicine , endocrinology , testosterone (patch) , cortisone , hormone , lumbar , cortisone acetate , parathyroid hormone , calcium , anatomy
SUMMARY The effect of estradiol, testosterone, cortisone acetate, somatotropin, thyro‐tropin and parathyroid hormone on the 2nd lumbar intervertebral disc in 18 growing dogs of non‐chondrodystropic breeds was investigated. Thirteen dogs aged one week to ten months were used as controls. Five of these were of the same litters as the hormone treated dogs. The results were estimated histologically and histochemically. Changes in the annulus fibrosus were observed especially in the groups treated with estradiol, testosterone, thyrotropin and to a lesser extent in the groups treated with somatotropin and cortisone acetate. Especially with the larger doses, the metachromasia of the intercellular substance increased, the structure became looser, fragmentation and homogenization occurred.