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The Influence of Certain Hormones on the Meniscus of the Femoro‐tibial (Stifle) Joint
Author(s) -
Rokkanen P.,
Paatsama S.,
Rissanen P.
Publication year - 1967
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.1967.tb04546.x
Subject(s) - medicine , hormone , endocrinology , meniscus , estrogen , androgen , physics , incidence (geometry) , optics
— —The effect of estrogen, androgen, cortisone, growth hormone, thyrotropic hormone and parathyroid hormone on the menisci of the femoro‐tibial (stifle) joint was studied in 17 puppies ranging from 2 to 24 weeks of age. Five dogs of the same litters were used as controls. The results were evaluated histologically and by a histoquantitative line sampling method. The estrogen‐treated group showed the greatest changes. In the female dogs there was a relative increase in intercellular substance and cyst‐like formations containing a metachromatically staining homogenous mass, indicating degeneration, were seen. The intercellular substance was also increased in the other dogs, except those treated with the growth hormone and cortisone. In the present study it appears that the inhibitory effect of the sex hormones is associated with cystic degeneration of the meniscal tissues. The female dogs of the androgen group showed similar, although less pronounced changes. In the male dogs of the androgen and growth hormone groups the proportion of chondrocytes was less and the proportion of hyaline cartilage‐like tissue of the inner border of the meniscus was larger than in the other groups. Supported by a grant from Valtion Lääketieteellinen Toimikunta (State Medical Committee).