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Wnt5a: its signalling, functions and implication in diseases
Author(s) -
Kikuchi A.,
Yamamoto H.,
Sato A.,
Matsumoto S.
Publication year - 2012
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2011.02294.x
Subject(s) - wnt5a , wnt signaling pathway , hedgehog signaling pathway , biology , phenotype , signalling , signal transduction , microbiology and biotechnology , embryonic stem cell , signalling pathways , genetics , gene
Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways. Because the β‐catenin‐independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca 2+ pathway, Wnt5a regulates a variety of cellular functions, such as proliferation, differentiation, migration, adhesion and polarity. Consistent with the multiple functions of Wnt5a signalling, Wnt5a knockout mice show various phenotypes, including an inability to extend the embryonic anterior–posterior and proximal–distal axes in outgrowth tissues. Thus, many important roles of Wnt5a in developmental processes have been demonstrated. Moreover, recent reports suggest that the postnatal abnormalities in the Wnt5a signalling are involved in various diseases, such as cancer, inflammatory diseases and metabolic disorders. Therefore, Wnt5a and its signalling pathways could be important targets for the diagnosis and therapy for human diseases.