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Skeletal muscle fibre diversity and the underlying mechanisms
Author(s) -
Canepari M.,
Pellegrino M. A.,
D’Antona G.,
Bottinelli R.
Publication year - 2010
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2010.02118.x
Subject(s) - gene isoform , myosin , skeletal muscle , biology , functional diversity , phenotype , neuroscience , itga7 , myh7 , microbiology and biotechnology , anatomy , genetics , myosin light chain kinase , gene , ecology
The review first briefly summarizes how myosin isoforms have been identified as the major determinant of the functional variability among skeletal muscle fibres. The latter feature is a major characteristic of muscle fibres and a major basis of skeletal muscle heterogeneity and plasticity in vivo . Then, evidence is reported, which indicates that the properties of muscle fibres can vary with no change in the myosin isoform they express. Moreover, the physiological and pathological conditions (ageing, disuse, exercise training, muscular dystrophy) in which such myosin isoform independent change in functional properties occurs and the possible underlying mechanisms are considered. Finally, the known molecular bases of the functional differences among slow and fast isoforms are briefly dealt with.