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Orexins/hypocretins and aminergic systems
Author(s) -
Eriksson K. S.,
Sergeeva O. A.,
Haas H. L.,
Selbach O.
Publication year - 2010
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2009.02015.x
Subject(s) - orexin , serotonergic , neuroscience , wakefulness , excitatory postsynaptic potential , inhibitory postsynaptic potential , cholinergic , histaminergic , dopaminergic , orexin a , neuropeptide , psychology , medicine , serotonin , dopamine , receptor , electroencephalography
Orexin/hypocretin neurones in the posterior hypothalamus are mutually connected with noradrenergic, serotonergic, dopaminergic, histaminergic, and cholinergic neurone systems. They activate these targets by direct post‐synaptic and indirect pre‐synaptic mechanisms and in turn receive inhibitory feedback and excitatory feed forward control. With respect to behavioural state control, orexin/hypocretin neurones are conducting the orchestra of biogenic amines. This review highlights the role of these players in the control of energy administration, sleep–wake architecture, cortical activation, plasticity, and memory functions in health and disease.