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Roles of the actin‐binding proteins in intracellular Ca 2+ signalling
Author(s) -
Chun J. T.,
Santella L.
Publication year - 2009
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2008.01921.x
Subject(s) - microbiology and biotechnology , cytoskeleton , actin cytoskeleton , intracellular , actin remodeling , actin , profilin , actin remodeling of neurons , biology , endoplasmic reticulum , crosstalk , actin binding protein , mdia1 , biochemistry , cell , physics , optics
Starfish oocytes undergo massive intracellular Ca 2+ signalling during meiotic maturation and fertilization. Although the igniting stimulus of Ca 2+ mobilization may differ in different cell contexts, its final leverage is usually the Ca 2+ ‐releasing second messengers such as InsP 3 , cADPr and NAADP. The general scheme of intracellular Ca 2+ release is that the corresponding receptors for these molecules serve as ion channels to release free Ca 2+ from its internal stores such as the lumen of the endoplasmic reticulum. However, a growing body of evidence has suggested that intracellular Ca 2+ release can be strongly modulated by the actin cytoskeleton. Although it is known that Ca 2+ contributes to remodelling of the actin cytoskeleton, whether the actin cytoskeleton modulates Ca 2+ signalling in return has not been much explored. An emerging candidate to answer to this reciprocal causality of Ca 2+ and the actin cytoskeleton may be actin‐binding proteins. In this review, we discuss how the actin cytoskeleton may fit into the known mechanisms of intracellular Ca 2+ release, and propose two models to explain the experimental data.