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Local Ca 2+ influx through CRAC channels activates temporally and spatially distinct cellular responses
Author(s) -
Parekh A. B.
Publication year - 2009
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2008.01919.x
Subject(s) - microbiology and biotechnology , intracellular , second messenger system , paracrine signalling , function (biology) , chemistry , biophysics , biology , biochemistry , receptor
Ca 2+ entry through store‐operated Ca 2+ release‐activated Ca 2+ (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca 2+ influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca 2+ rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro‐inflammatory molecule LTC 4 . In addition, local Ca 2+ entry can activate gene expression, which develops over tens of minutes. Local Ca 2+ influx through CRAC channels therefore has far‐reaching consequences on intra‐ and intercellular communication.