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Involvement of endothelin‐1 in habitual exercise‐induced increase in arterial compliance
Author(s) -
Maeda S.,
Sugawara J.,
Yoshizawa M.,
Otsuki T.,
Shimojo N.,
Jesmin S.,
Ajisaka R.,
Miyauchi T.,
Tanaka H.
Publication year - 2009
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2008.01909.x
Subject(s) - aerobic exercise , medicine , compliance (psychology) , endothelin receptor , blood pressure , physical exercise , exercise physiology , cardiology , endothelin 1 , receptor , psychology , social psychology
Aim: Habitual aerobic exercise results in a significant increase in central arterial compliance. Endothelin‐1 (ET‐1) is a potent endothelium‐derived vasoconstrictor peptide and could play a role in mediating the habitual aerobic exercise‐induced increase in central arterial compliance. The aim of the present study was to examine whether ET‐1 is involved in the mechanisms underlying the increase in central arterial compliance with aerobic exercise training. Methods: Seven apparently healthy middle‐aged and older (60 ± 3 years) adults underwent systemic endothelin‐A/B (ET A/B )‐receptor blockade (500 mg of Tracleer ® ) before and after 12 weeks of aerobic exercise training (70 ± 1% of maximal heart rate, 44 ± 2 min day −1 , 4.4 ± 0.1 days week −1 ). Results: Basal carotid arterial compliance (via simultaneous B‐mode ultrasound and arterial applanation tonometry on the common carotid artery) increased significantly after exercise training. Resting plasma ET‐1 concentration decreased significantly after exercise training. Before exercise intervention, carotid arterial compliance increased significantly with the administration of the ET A/B ‐receptor blockade. After training, however, increases in carotid arterial compliance previously observed with the ET A/B ‐receptor blockade before training were abolished. Conclusions: Regular aerobic exercise training enhances central arterial compliance in middle‐aged and older humans. The increase in arterial compliance was associated with the corresponding reduction in plasma ET‐1 concentration as well as the elimination of ET‐1‐mediated vascular tone. These results suggest that reductions in ET‐1 may be an important mechanism underlying the beneficial effect of exercise training on central artery compliance.