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Compensatory endocytosis in chromaffin cells
Author(s) -
Barg S.,
Machado J. D.
Publication year - 2008
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2007.01813.x
Subject(s) - exocytosis , endocytosis , secretion , microbiology and biotechnology , granule (geology) , chromaffin cell , biology , lipid bilayer fusion , membrane , cell , neuroscience , adrenal medulla , biochemistry , catecholamine , paleontology
Exocytosis occurs via fusion of secretory granules with the cell membrane, whereupon the granule content is at least partially released and the granule membrane is temporarily added to the plasma membrane. Exocytosis is balanced by compensatory endocytosis to achieve net equilibrium of the cell surface area and to recycle and redistribute components of the exocytosis machinery. The underlying molecular mechanisms remain a matter of debate. In this review, we summarize and discuss recent progress in the understanding of compensatory endocytosis, with the focus on chromaffin cells as a useful model for studying mechanisms of regulated secretion.