Premium
Effect of the oestral cycle on respiratory mechanics in the rat
Author(s) -
Rubini A.,
Bondì M.
Publication year - 2007
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/j.1748-1716.2007.01671.x
Subject(s) - respiratory system , lung , estrous cycle , respiratory physiology , pulmonary surfactant , hormone , medicine , endocrinology , anesthesia , physics , thermodynamics
Aim: To assess the effect of the oestral cycle on the respiratory mechanics of the rat. Methods: We measured the main mechanical respiratory parameters, namely respiratory system and lung resistances and compliances, by the end‐inflation occlusion method on two populations of female rats, during proestrous–oestrous and metaoestrous–diestrous phases. Results: Inflation–deflation loops of the lungs were found to be statistically higher in rats during metaoestrous–diestrous phase. No other statistically significant difference was found in the measured mechanical respiratory parameters. Conclusion: Our results suggest that the naturally occurring fluctuations in serum sexual hormone levels during the sexual cycle influence the lung's hysteresis but do not influence the respiratory system and lung resistances or static compliances. A possible effect of female sexual hormones on surfactant activity is also suggested.