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Novel Benzimidazole Analogs as Inhibitors of EGFR Tyrosine Kinase
Author(s) -
Yadav Soni,
Sinha Deepa,
Singh Sanjay K.,
Singh Vinay K.
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2012.01407.x
Subject(s) - benzimidazole , in vitro , in vivo , chemistry , tyrosine kinase , tyrosine kinase inhibitor , stereochemistry , pharmacology , combinatorial chemistry , biochemistry , biology , signal transduction , organic chemistry , cancer , microbiology and biotechnology , genetics
A series of new benzimidazole congeners were synthesized, and their structures were elucidated on the basis of elemental analyses and spectral studies ( 1 H NMR, FT‐IR and EI‐MS). Preliminary pharmacokinetic studies showed a promising outlook for further in vivo evaluation. The newly synthesized compounds were tested in vitro on human breast carcinoma cell line (MCF‐7) in which EGFR is highly expressed. Most of the tested compounds exhibited antitumor activity with IC 50 values in the micro to nano molar range.