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In Vitro Antioxidant Activity Study of Novel Chromone Derivatives
Author(s) -
Phosrithong Narumol,
Samee Weerasak,
Nunthanavanit Patcharawee,
Ungwitayatorn Jiraporn
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2012.01368.x
Subject(s) - chromone , in vitro , antioxidant , chemistry , biochemistry , stereochemistry , combinatorial chemistry
Forty‐eight chromone derivatives were evaluated for their antioxidant activity using 2,2‐diphenyl‐1‐picrylhydrazyl free radical scavenging assay, ferrous ions (Fe 2+ ) chelating activity test, total antioxidant activity test (Ferric thiocyanate and Thiobarbituric acid methods), and total reductive capability (potassium ferricyanide reduction). 7,8‐Dihydroxy‐2‐(3′‐trifluoromethylphenyl)‐3‐(3″‐trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated hydroxytoluene, vitamin E, and trolox. Chromone derivatives that exhibited good radical scavenging and metal chelating also displayed strong total antioxidant and reductive power activities. The results obtained from this study indicated that the synthesized chromone derivatives have remarkable antioxidant activity.