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Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
Author(s) -
Franco Lucas Lopardi,
de Almeida Mauro Vieira,
e Silva Luiz Francisco Rocha,
Vieira Pedro Paulo Ribeiro,
Pohlit Adrian Martin,
Valle Marcelo Siqueira
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2012.01345.x
Subject(s) - plasmodium falciparum , in vitro , acetone , malaria , chemistry , conjugated system , malarial parasites , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , biology , immunology , polymer
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μ m ≤ IC 50 ≤ 5.0 μ m ) against blood forms of the human malaria parasite Plasmodium falciparum .