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Natural Products as Sources of New Fungicides: Synthesis and Antifungal Activity of Zopfiellin Analogues
Author(s) -
Musso Loana,
Dallavalle Sabrina,
Farina Gandolfina,
Burrone Elio
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2012.01343.x
Subject(s) - oomycete , fungicide , phytophthora infestans , pythium ultimum , antifungal , in vivo , chemistry , in vitro , biology , stereochemistry , botany , microbiology and biotechnology , biochemistry , rhizoctonia solani , blight , pathogen
The synthesis of a series of cyclooctadiene anhydrides, analogues of the natural compound zopfiellin, was performed to assay their in vitro and in vivo antifungal activity on a set of plant pathogenic fungi. Most of the synthesized compounds possessed a broad spectrum of activity. In particular, the anhydrides 2 and 5a were very effective against the Oomycete diseases such as Phytophthora infestans and Pythium ultimum , reaching a level of activity well comparable with that of commercial fungicides in use. Preliminary in vivo evaluation of their protectant activity is also reported.