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Synthesis and Antitumor Activity of Dehydroepiandrosterone Derivatives on Es‐2, A549, and HepG2 Cells in vitro
Author(s) -
Liu XueKun,
Ye BaiJun,
Wu Yan,
Nan JiXing,
Lin ZhenHua,
Piao HuRi
Publication year - 2012
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01311.x
Subject(s) - dehydroepiandrosterone , in vitro , a549 cell , chemistry , mtt assay , inhibitory postsynaptic potential , biochemistry , pharmacology , stereochemistry , microbiology and biotechnology , endocrinology , biology , hormone , androgen
A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES‐2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c , 2i , and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES‐2 cells, A549 cells, and HepG2 cells, respectively.