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Antifungal Agents. Part 3: Synthesis and Antifungal Activities of 3‐Acylindole Analogs against Phytopathogenic Fungi In Vitro
Author(s) -
Xu Hui,
bin Yang Wen,
Wang Qin
Publication year - 2011
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01212.x
Subject(s) - fungicide , antifungal , in vitro , biology , chemistry , stereochemistry , biochemistry , botany , microbiology and biotechnology
To find more potent antifungal compounds, twenty 3‐acylindole analogs were synthesized and bio‐evaluated for their antifungal activities against seven phytopathogenic fungi. Structure–activity relationships investigations revealed that 4‐ or 6‐methyl and 3‐acetyl or propionyl groups were the important structural properties of 3‐acylindoles for the activities. Especially 4‐methyl‐3‐propionylindole, 12 , displayed the more potent activities than hymexazol, a commercially available agricultural fungicide, and might be considered as a new promising lead candidate for further design and synthesis of agricultural fungicides.