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Synthesis and Anti‐Hypercholesterolemic Evaluations of Calcium Salts of 4‐Substituted Quinoline‐Based Mevalonic Acid
Author(s) -
Hao Qun,
Cai Zhengyan,
Pan Jing,
Li Yongjia,
Xia Yuye,
Min Yang,
Sheng Yuchen,
Zhou Weicheng
Publication year - 2011
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01198.x
Subject(s) - quinoline , atorvastatin , chemistry , calcium , cholesterol , mevalonic acid , stereochemistry , biochemistry , pharmacology , organic chemistry , enzyme , biology , biosynthesis
A series of calcium (3R,5S,6E)‐7‐[4,6,7,8‐substituted‐quinoline‐3‐yl]‐3,5‐dihydroxy‐hept‐6‐enoates was synthesized from the lactones, and the anti‐hypercholesterolemic evaluation in quails was presented in this report. It was found that most of the compounds significantly decreased levels of total cholesterol and low‐density lipoprotein. 2e showed better hypolipidemic effect than atorvastatin, and 2d and 2j exhibited comparable efficacy to atorvastatin. These three compounds were selected as the hypocholesterolemic candidates for further evaluation.