Premium
Synthesis, Antifungal Activity, and Docking Study of Some New 1,2,4‐triazole Analogs
Author(s) -
Sangshetti Jaiprakash N.,
Lokwani Deepak K.,
Sarkate Aniket P.,
Shinde Devanand B.
Publication year - 2011
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01178.x
Subject(s) - lanosterol , docking (animal) , triazole , chemistry , stereochemistry , 1,2,3 triazole , active site , antifungal , piperidine , 1,2,4 triazole , combinatorial chemistry , enzyme , biochemistry , organic chemistry , biology , microbiology and biotechnology , medicine , sterol , nursing , cholesterol
Synthesis of new series of 1,2,4‐triazole with 1,2,3‐triazole and piperidine ring using ZrOCl 2 ·8H 2 O as a catalyst in ethanol has been described. The yields obtained are in the range of 80–85%. All the synthesized compounds ( 3a – 3o ) are novel and were evaluated for their in vitro antifungal activities using standard agar method. Docking study of the newly synthesized compounds was performed, and results showed that all new compounds have similar binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14α‐demethylase.