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Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti‐Inflammatory Agents
Author(s) -
Burguete Asunción,
Pontiki Eleni,
HadjipavlouLitina Dimitra,
Ancizu Saioa,
Villar Raquel,
Solano Beatriz,
Moreno Elsa,
Torres Enrique,
Pérez Silvia,
Aldana Ignacio,
Monge Antonio
Publication year - 2011
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2011.01076.x
Subject(s) - quinoxaline , in vivo , chemistry , antioxidant , anti inflammatory , lipoxygenase , in vitro , pharmacology , combinatorial chemistry , biochemistry , enzyme , organic chemistry , medicine , biology , microbiology and biotechnology
We report the synthesis, anti‐inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4‐di‐ N ‐oxide derivatives. Microwave‐assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f ) were evaluated as in vivo anti‐inflammatory agents using the carrageenin‐induced edema model. One of them (compound 7b ) showed important in vivo anti‐inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.