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Design, Synthesis, Docking and Antitumor Activity of Quinazolino [3, 4‐a] thieno [3, 2‐d] pyrimidin‐8‐one Derivatives
Author(s) -
Zheng Youguang,
Wu Xiaoqing,
Xue Bai,
Li Mingdong,
Ji Min
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2010.01008.x
Subject(s) - docking (animal) , chemistry , in vitro , combinatorial chemistry , du145 , stereochemistry , biochemistry , cancer cell , medicine , cancer , nursing , lncap
Several novel quinazolino [3, 4‐a] thieno [3, 2‐d] pyrimidin‐8‐one derivatives were synthesized. All of the compounds were determined against MiaPaCa2 and DU145 cells in vitro , and the crystal structures of analog 8 and 20 in the active site of the EGFR complexes were presented. The entire compounds had been identified by 1 HNMR, 13 CNMR, IR, MS and EA.