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Synthesis and Antitumor Activity of 5′‐deoxy‐4′‐thio‐ l ‐nucleosides
Author(s) -
Cong Liqing,
Zhou Weicheng,
Jin Dongzhe,
Wang Juan,
Chen Xiuhua
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2010.00967.x
Subject(s) - thio , in vitro , chemistry , absolute configuration , cell culture , stereochemistry , purine , human breast , cancer cell lines , biochemistry , cancer , cancer cell , biology , enzyme , genetics
A series of novel 5′‐deoxy‐4′‐thio‐ l ‐nucleosides was designed and synthesized. The absolute configuration of the target compound 23α was confirmed by X‐ray crystallography. The antitumor activities of the target compounds were tested against the growth of human carcinoma of colon (LOVO), human leukemia cell line (CEM) and human breast cancer cell line (MDA‐MB‐435) cells in vitro . 6‐cyclopentylamino and 6‐cyclohexylamino purine compounds 26 and 27, both in α‐configuration and in β‐form, exhibited strong inhibition to CEM.