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Chromene‐Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity
Author(s) -
Foroumadi Alireza,
Emami Saeed,
Sorkhi Maedeh,
Nakhjiri Maryam,
Nazarian Zohreh,
Heydari Samaneh,
Ardestani Sussan K.,
Poorrajab Fatemeh,
Shafiee Abbas
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2010.00959.x
Subject(s) - chemistry , leishmania , in vitro , chalcone , biological activity , leishmania major , leishmaniasis , combinatorial chemistry , stereochemistry , cytotoxicity , biochemistry , biology , immunology , parasite hosting , world wide web , computer science
Two types of regioisomeric chromene‐based chalcones namely, 1‐(6‐methoxy‐2 H ‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones and 3‐(6‐methoxy‐2 H ‐chromen‐3‐yl)‐1‐phenylpropen‐1‐ones were prepared and investigated for their antileishmanial activity against promastigotes form of Leishmania major . The obtained results from in vitro biological assays indicated that chloro‐substituted 1‐(6‐methoxy‐2 H ‐chromen‐3‐yl)‐3‐phenylpropen‐1‐ones exhibited excellent activity against Leishmania major at non‐cytotoxic concentrations.