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Design of a Versatile Multicomponent Reaction Leading to 2‐amino‐5‐ketoaryl pyrroles
Author(s) -
Wang Kan,
Dömling Alexander
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00942.x
Subject(s) - pharmacophore , cyanoacetic acid , chemistry , combinatorial chemistry , amino acid , reaction conditions , organic chemistry , stereochemistry , biochemistry , catalysis
The design of an unprecedented multicomponent reaction to and synthesis of 2‐amino‐5‐ketoaryl pyrroles are described. The compounds (14 examples) can be synthesized by reacting aminoacetophenone sulfonamides, (hetero)aromatic aldehydes, and malonodinitrile or cyanoacetic acid derivatives in one‐pot manner. Pharmacophore features and potential applications of this new scaffold are discussed.