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Select Acetophenones Modulate Flagellar Motility in Chlamydomonas
Author(s) -
Evans Shakila K.,
Pearce Austin A.,
Ibezim Prudence K.,
Primm Todd P.,
Gaillard Anne R.
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00933.x
Subject(s) - chlamydomonas , phototaxis , motility , flagellum , microbiology and biotechnology , biology , gliding motility , chemistry , biophysics , biochemistry , botany , mutant , gene
Acetophenones were screened for activity against positive phototaxis of Chlamydomonas cells, a process that requires co‐ordinated flagellar motility. The structure–activity relationships of a series of acetophenones are reported, including acetophenones that affect flagellar motility and cell viability. Notably, 4‐methoxyacetophenone, 3,4‐dimethoxyacetophenone, and 4‐hydroxyacetophenone induced negative phototaxis in Chlamydomonas , suggesting interference with activity of flagellar proteins and control of flagellar dominance.