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Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols
Author(s) -
Coimbra Elaine S.,
De Almeida Mauro V.,
Júnior Celso O. R.,
Taveira Aline F.,
Da Costa Cristiane F.,
De Almeida Ana C.,
Reis Elaine F. C.,
Da Silva Adilson D.
Publication year - 2010
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00923.x
Subject(s) - leishmania chagasi , chemistry , leishmania , in vitro , drug , biochemistry , stereochemistry , active compound , amino acid , leishmaniasis , pharmacology , biology , visceral leishmaniasis , immunology , parasite hosting , world wide web , computer science
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi . Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC 50 below 10 μ m . Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.