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Antimalarial Activity of the Novel Quinoline/6‐Thiopurine Conjugate in Gallus gallus Linnaeus, Infected Experimentally by Plasmodium ( Novyella ) juxtanucleare
Author(s) -
Vashist Usha,
Carvalhaes Rafael,
D’agosto Marta,
Da Silva Adilson David
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00877.x
Subject(s) - thiopurine methyltransferase , conjugate , quinoline , malaria , pharmacology , chloroquine , biology , chemistry , virology , medicine , immunology , azathioprine , mathematical analysis , mathematics , disease , organic chemistry
This study aimed to evaluate the 4‐(6′‐thiopurine)‐7‐chloroquinoline, a novel quinoline/6‐thiopurine conjugate, for the treatment of Gallus gallus experimentally infected with Plasmodium juxtanucleare , an avian malaria agent. The avian group treated with 4‐(6′‐thiopurine)‐7‐chloroquinoline showed a significative parasite clearance and maintained a low level of parasitaemia, when compared with the untreated control group and to the chloroquine treated avian group.