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Inhibition of Quorum Sensing in Vibrio harveyi by Boronic Acids
Author(s) -
Ni Nanting,
Choudhary Gaurav,
Peng Hanjing,
Li Minyong,
Chou HanTing,
Lu ChungDar,
Gilbert Eric S.,
Wang Binghe
Publication year - 2009
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/j.1747-0285.2009.00834.x
Subject(s) - quorum sensing , vibrio harveyi , biofilm , autoinducer , boronic acid , bacteria , virulence , microbiology and biotechnology , vibrio , bacterial cell structure , chemistry , biology , biochemistry , gene , combinatorial chemistry , genetics
Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chemicals called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. In this paper, we describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC 50 values in the low to sub‐micromolar range in whole cell assays.